Primer on Disproportionality Analysis
ثبت نشده
چکیده
This primer explains meaning, calculation and uses of various methods for assessing disproportionality in pharmacovigilance data by observed-expected ratios. Disproportionality can stimulate further research whether an adverse event (AE) should be considered an adverse drug reaction (ADR). Disproportionality analysis is thus only suited for hypothesis generation, not for hypothesis testing. Note the cave-at documents from OpenVigil, FDA and WHO before drawing any conclusions from the ratios presented and explained below [1].
منابع مشابه
Comparison of indices of disproportionality in PR systems
Comparative analysis of 12 indices of disproportionality by such characteristics as: metric, definition domain, representation uniformity, invariance and utilization field, is done. As a result of comparison, the opportunity to use as index of disproportionality in elections the Average relative deviation one is argued. Graphic representation for the upper limit of optimal solutions’ disproport...
متن کاملPatterns in nursing home medication errors: disproportionality analysis as a novel method to identify quality improvement opportunities.
PURPOSE To explore the use of disproportionality analysis of medication error data as a novel method to identify relationships that might not be obvious through traditional analyses. This approach can supplement descriptive data and target quality improvement efforts. METHODS Data came from the Medication Error Quality Initiative (MEQI) individual event reporting system. Participants were Nor...
متن کاملvigiRank for statistical signal detection in pharmacovigilance: First results from prospective real‐world use
PURPOSE vigiRank is a data-driven predictive model for emerging safety signals. In addition to disproportionate reporting patterns, it also accounts for the completeness, recency, and geographic spread of individual case reporting, as well as the availability of case narratives. Previous retrospective analysis suggested that vigiRank performed better than disproportionality analysis alone. The ...
متن کاملON SHARING NATO DEFENSE BURDENS IN THE 1990s AND BEYOND
This article investigates NATO burden sharing in the 1990s in light of strategic, technological, political, and membership changes. Both an ability-to-pay and a benefits-received analysis of burden sharing are conducted. During 1990-99, there is no evidence of disproportionate burden sharing, where the large allies shoulder the burdens of the small. Nevertheless, the theoretical model predicts ...
متن کاملA note on "Measurement of disproportionality in proportional representation systems"
In this paper, we add three further indices to the survey on disproportionality by Karpov. Two of them are rooted in the issue of power, so we discuss the relevance of it in evaluating the disproportionality of a Parliament w.r.t. the voting body.
متن کامل